Gene symbol |
Protein | OMIM | Number of exons (coding exons) |
Chromosome location |
Germline mutations |
Somatic mutations |
---|---|---|---|---|---|---|
HRAS | HRAS | 190020 | 6(5) | 11p15.5 | Costello | Bladder carcinoma |
KRAS | KRAS | 190070 | 6(5) | 12p12.1 | Noonan, CFC | Lung, colon and pancreatic cancer |
BRAF | BRAF | 164757 | 18(18) | 7q34 | CFC | Malignant melanoma, colon cancer, thyroid cancer |
MAP2K1 | MEK1 | 176872 | 11(11) | 15q22 | CFC | — |
MAP2K2 | MEK2 | 601263 | 11(11) | 19p13.3 | CFC | — |
PTPN11 | SHP-2 | 176876 | 16(15) | 12q24.1 | Noonan, LEOPARD |
JMML, AML, ALL, MDS,CML, solid tumors |